A 28-yr-old female California sea lion (Zalophus californianus) in a commercial aquarium developed an ulcerated lingual tumor and died. Necropsy revealed a moderately differentiated squamous cell carcinoma. Immunohistochemical staining and electron microscopic studies revealed that the tumor cells were strongly positive with anti–keratin-cytokeratin antibody and had abundant tonofibrils and desmosomes. The neoplasm had metastasized to a mandibular lymph node.
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1 December 2002
LINGUAL SQUAMOUS CELL CARCINOMA IN A CALIFORNIA SEA LION (ZALOPHUS CALIFORNIANUS)
Tsuneo Sato,
Tomomi Higuchi,
Hisashi Shibuya,
Shigeo Ohba,
Sadao Nogami,
Wataru Shirai,
Hideaki Watanabe,
Shigeaki Honda
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Journal of Zoo and Wildlife Medicine
Vol. 33 • No. 4
December 2002
Vol. 33 • No. 4
December 2002
California sea lion
electron microscopy
immunohistochemical staining
lingual
squamous cell carcinoma
Zalophus californianus